MaghrebDataLibMedV2, Main, Exploration, bibRecord, 000427

Looking for New Antifungal Drugs from Flavonoids: Impact of the Genetic Diversity of Candida albicans on the in-vitro Response.

Identifieur interne : 000427 ( Main/Exploration ); précédent : 000426; suivant : 000428

Looking for New Antifungal Drugs from Flavonoids: Impact of the Genetic Diversity of Candida albicans on the in-vitro Response.

Auteurs : Maria Rosa Felice [Italie] ; Letterio Giuffrè [Italie] ; Lamya El Aamri [Italie, Maroc] ; Majida Hafidi [Maroc] ; Giuseppe Criseo [Italie] ; Orazio Romeo [Italie] ; Fabio Scordino [Italie]

Source :

Current medicinal chemistry [ 1875-533X ] ; 2019.

RBID : pubmed:29278204

Descripteurs français

KwdFr :
- Antifongiques (pharmacologie), Candida albicans (effets des médicaments et des substances chimiques), Candida albicans (génétique), Flavonoïdes (pharmacologie), Tests de sensibilité microbienne (MeSH), Variation génétique (effets des médicaments et des substances chimiques), Variation génétique (génétique).
MESH :
- effets des médicaments et des substances chimiques : Candida albicans, Variation génétique.
- génétique : Candida albicans, Variation génétique.
- pharmacologie : Antifongiques, Flavonoïdes.
- Tests de sensibilité microbienne.

English descriptors

KwdEn :
- Antifungal Agents (pharmacology), Candida albicans (drug effects), Candida albicans (genetics), Flavonoids (pharmacology), Genetic Variation (drug effects), Genetic Variation (genetics), Microbial Sensitivity Tests (MeSH).
MESH :
- chemical , pharmacology : Antifungal Agents, Flavonoids.
- drug effects : Candida albicans, Genetic Variation.
- genetics : Candida albicans, Genetic Variation.
- Microbial Sensitivity Tests.

Abstract

BACKGROUND

In an era in which antimicrobial resistance is increasing at an alarming pace, it is very important to find new antimicrobial agents effective against pathogenic microrganisms resistant to traditional treatments. Among the notable breakthroughs in the past years of research in natural-drug discovery, there is the identification and testing of flavonoids, a group of plant-derived substances capable of promoting many beneficial effects on humans. These compounds show different biological activities such as inhibition of neuroinflammation and tumor growth as well as antimicrobial activity against many microbial pathogens.

METHODS

We undertook a review of protocols and standard strains used in studies reporting the inhibitory effects of flavonoids against Candida albicans by focusing our attention on genetic characterization of the strains examined. Moreover, using the C. albicans MLST-database, we performed a phylogenetic analysis showing the genetic variation occurring in this species.

RESULTS

Today, we have enough information to estimate genetic diversity within microbial species and recent data revealed that most of fungal pathogens show complex population structures in which not a single isolate can be designated as representative of the entire taxon. This is especially true for the highly divergent fungal pathogen C. albicans, in which the assumption that one or few "standard strains" can represent the whole species is overly unrealistic and should be laid to rest.

CONCLUSION

The goal of this article is to shed light on the extent of genetic variation in C. albicans and how this phenomenon can largely influence the activity of flavonoids against this species.

DOI: 10.2174/0929867325666171226102700
PubMed: 29278204

Affiliations:

Italie, Maroc

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Le document en format XML

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<wicri:noRegion>Messina</wicri:noRegion>
</affiliation>
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<author><name sortKey="Scordino, Fabio" sort="Scordino, Fabio" uniqKey="Scordino F" first="Fabio" last="Scordino">Fabio Scordino</name>
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<series><title level="j">Current medicinal chemistry</title>
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<term>Candida albicans (drug effects)</term>
<term>Candida albicans (genetics)</term>
<term>Flavonoids (pharmacology)</term>
<term>Genetic Variation (drug effects)</term>
<term>Genetic Variation (genetics)</term>
<term>Microbial Sensitivity Tests (MeSH)</term>
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<term>Candida albicans (effets des médicaments et des substances chimiques)</term>
<term>Candida albicans (génétique)</term>
<term>Flavonoïdes (pharmacologie)</term>
<term>Tests de sensibilité microbienne (MeSH)</term>
<term>Variation génétique (effets des médicaments et des substances chimiques)</term>
<term>Variation génétique (génétique)</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antifungal Agents</term>
<term>Flavonoids</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Candida albicans</term>
<term>Genetic Variation</term>
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<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Candida albicans</term>
<term>Variation génétique</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Candida albicans</term>
<term>Genetic Variation</term>
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<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Candida albicans</term>
<term>Variation génétique</term>
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<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antifongiques</term>
<term>Flavonoïdes</term>
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<keywords scheme="MESH" xml:lang="en"><term>Microbial Sensitivity Tests</term>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>In an era in which antimicrobial resistance is increasing at an alarming pace, it is very important to find new antimicrobial agents effective against pathogenic microrganisms resistant to traditional treatments. Among the notable breakthroughs in the past years of research in natural-drug discovery, there is the identification and testing of flavonoids, a group of plant-derived substances capable of promoting many beneficial effects on humans. These compounds show different biological activities such as inhibition of neuroinflammation and tumor growth as well as antimicrobial activity against many microbial pathogens.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>We undertook a review of protocols and standard strains used in studies reporting the inhibitory effects of flavonoids against Candida albicans by focusing our attention on genetic characterization of the strains examined. Moreover, using the C. albicans MLST-database, we performed a phylogenetic analysis showing the genetic variation occurring in this species.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Today, we have enough information to estimate genetic diversity within microbial species and recent data revealed that most of fungal pathogens show complex population structures in which not a single isolate can be designated as representative of the entire taxon. This is especially true for the highly divergent fungal pathogen C. albicans, in which the assumption that one or few "standard strains" can represent the whole species is overly unrealistic and should be laid to rest.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>The goal of this article is to shed light on the extent of genetic variation in C. albicans and how this phenomenon can largely influence the activity of flavonoids against this species.</p>
</div>
</front>
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<name sortKey="Giuffre, Letterio" sort="Giuffre, Letterio" uniqKey="Giuffre L" first="Letterio" last="Giuffrè">Letterio Giuffrè</name>
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<name sortKey="Romeo, Orazio" sort="Romeo, Orazio" uniqKey="Romeo O" first="Orazio" last="Romeo">Orazio Romeo</name>
<name sortKey="Scordino, Fabio" sort="Scordino, Fabio" uniqKey="Scordino F" first="Fabio" last="Scordino">Fabio Scordino</name>
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<country name="Maroc"><noRegion><name sortKey="El Aamri, Lamya" sort="El Aamri, Lamya" uniqKey="El Aamri L" first="Lamya" last="El Aamri">Lamya El Aamri</name>
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Looking for New Antifungal Drugs from Flavonoids: Impact of the Genetic Diversity of Candida albicans on the in-vitro Response.

Looking for New Antifungal Drugs from Flavonoids: Impact of the Genetic Diversity of Candida albicans on the in-vitro Response.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki